When Autoimmunity 'DRESSes up': A Case after Certolizumab Therapy.

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is characterised by skin rash together with visceral organ involvement, lymphadenopathy, eosinophilia and atypical lymphocytosis. The syndrome is clinically heterogeneous, making diagnosis challenging. It has an annual incidence of 2 per 100,000 population and a mortality rate of 2-10%. We describe the first case of DRESS induced by certolizumab, a biologic disease-modifying antirheumatic drug (bioDMARD). LEARNING POINTS: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is an uncommon and under-reported syndrome.Its recognition is critical for treatment, especially in the emergency setting where most patients first present.In the case of unexplained fever, lymphadenopathy, cutaneous rash and characteristic laboratory findings (e.g., eosinophilia), after infectious causes have been ruled out, clinicians should always keep DRESS in mind and consider possible recent intake of a triggering drug.

Relationship between daily physical activity and aerobic fitness in adults with cystic fibrosis.

BACKGROUND: The best clinical practice to investigate aerobic fitness includes measurements obtained during cardiopulmonary exercise testing (CPET), however it remains an underutilised clinical measure in cystic fibrosis (CF). To investigate this further, different methods of quantifying exercise capacity in CF are required. The possibility that measuring physical activity (PA) by a portable accelerometer could be used to assess the CF aerobic state and could be added among the CPET surrogates has not been investigated. The aim of this study was to examine the relationship between PA and exercise fitness both at submaximal and maximal levels in clinically stable adults with CF. METHODS: Thirty CF patients (FEV1 71 ± 19% predicted) and fifteen healthy controls undertook an incremental CPET on a cycle ergometer. CPET-related measurements included: oxygen uptake (V'O2), carbon dioxide production (V'CO2), ventilatory profile, heart rate (HR) and oxygen pulse (V'O2/HR) throughout exercise and at lactic threshold (LT) and peak. LT measures represent submaximal exercise related data. PA was assessed using the accelerometer SenseWear Pro3 Armband. RESULTS: Moderate (>4.8 metabolic equivalents (METS)) and moderate + vigorous (>7.2 METS) PA was related to V'O2 (p = 0.005 and p = 0.009, respectively) and work rate (p = 0.004 and p = 0.002, respectively) at LT. Moderate PA or greater was positively related to peak V'O2 (p = 0.005 and p = 0.003, respectively). Daily PA levels were similar in CF and healthy controls. Except for peak values, V'O2 profile and the V'O2 at LT were comparable between CF and healthy controls. CONCLUSIONS: In adult CF patients daily PA positively correlated with aerobic capacity. PA measurements are a valuable tool in the assessment of exercise performance in an adult CF population and could be used for interventional exercise trials to optimize exercise performance and health status. PA levels and parameters obtained at submaximal exercise are similar in CF and in healthy controls.

Impact of chronic obstructive pulmonary disease on exercise ventilatory efficiency in heart failure.

BACKGROUND: Heart failure (HF) and chronic obstructive pulmonary disease (COPD) coexistence increases morbidity and mortality. The intercept of ventilation (VEint) on the VE vs. carbon dioxide production (VCO2) relationship during exercise has been found to vary in proportion with dead space (VD) in HF. Considering that increased VD is the key pathophysiological abnormality in COPD but a secondary finding in HF we hypothesized that a high VEint would be useful in suggesting COPD as HF co-morbidity. Our aim was to assess whether an elevated VEint suggests the presence of COPD in HF. METHODS: In a multicenter retrospective study, the VE-VCO2 relationship was analyzed both as slope and intercept in HF (n = 108), HF-COPD (n = 106) and COPD (n = 95). Patients with pulmonary arterial hypertension (PAH) (n = 85) and healthy subjects (HF) (n = 56) served as positive and negative controls relative to VE-VCO2 abnormalities, respectively. RESULTS: Slope and VEint varied in opposite directions in all groups (p < 0.05) being VE-VCO2 slope highest and lowest in PAH and healthy subjects, respectively. No slope differences were observed among HF, HF-COPD and COPD (32 ± 7, 31 ± 7, and 31 ± 6, respectively). VEint was higher in HF-COPD and COPD compared to HF, PAH and controls (4.8 ± 2.4 L/min, 5.9 ± 3.0 L/min, 3.0 ± 2.6L/min, 2.3 ± 3.3 L/min and 3.9 ± 2.5L/min, respectively; p < 0.01). A VEint ≥ 4.07 L/min identified patients with high probability of having COPD or HF-COPD (sensitivity of 71.6% and specificity of 72.0%). CONCLUSION: These data provide novel evidence that a high VEint (≥ 4.07 L/min) should be valued to suggest coexistent COPD in HF patients.

Measuring habitual physical activity in adults with cystic fibrosis.

BACKGROUND: The aim of the present study was to determine whether different methods of recording physical activity (PA), i.e., accelerometers vs questionnaires, provided similar information in adults with cystic fibrosis (CF). METHODS: 20 CF (age 33 ± 8SD yrs, FEV1 68 ± 16% predicted) and 11 age-matched healthy controls completed the Habitual Activity Estimation Scale (HAES) questionnaire and wore a biaxial accelerometer (SenseWear Pro3 Armband). Exercise tolerance was measured in CF. RESULTS: Patients had similar values in PA compared with controls. None of PA categories estimated by HAES questionnaire correlated with PA categories measured by the accelerometer; in CF the HAES questionnaire overestimated the effective levels of PA measured by the accelerometer. There were no differences between weekdays and weekend days PA levels provided by the accelerometer. In CF the questionnaire detected different time reported during the "somewhat inactive" and "somewhat active" categories (z = 2.651; p = 0.008; z = -2.651; p = 0.008), weekdays vs weekend; patients reported more time spent in activity (somewhat active & very active) during the weekend (z = -2.203; p = 0.02). Peak oxygen uptake correlated with accelerometer activities of "moderate" (>4.8 metabolic equivalents (METS)) and "vigorous" (>7.2 METS) intensity (r = 0.503, p = 0.02; r = 0.545, p = 0.01). CONCLUSIONS: In adults with cystic fibrosis PA levels are better evaluated by the accelerometer and are similar to the controls. PA measured by the accelerometer is similar during the week and correlates with exercise tolerance.

Minute ventilation and heart rate relationship for estimation of the ventilatory compensation point at high altitude: a pilot study.

BACKGROUND: The ventilatory compensation point (VCP) is an exercise threshold which has been used in the design of training programs in sports medicine and rehabilitation. We recently demonstrated that changes in the slope of the minute ventilation to heart rate relationship (ΔV˙E/ΔHR) can be utilized for estimation of the VCP during incremental exercise at sea level (SL). We hypothesized that in hypoxic conditions, such as high altitude (HA), VCP can be also reliably estimated by ΔV˙E/ΔHR. METHODS: At SL and on immediate ascent to HA (5,050 m), six healthy subjects (42 ± 14 SD years) performed a maximal incremental exercise test on a cycle ergometer; O2 uptake (V˙O2), CO2 output (V˙CO2), V˙E, and HR were measured breath-by-breath. The ΔV˙E/ΔHR method for VCP estimation was compared to the standard method using the ventilatory equivalent for CO2 (V˙E/V˙CO2) and end-tidal PCO2 (PETCO2). The ΔV˙E/ΔHR slope values below (S1) and above (S2) VCP were computed by linear regression analysis. RESULTS: A significant difference between S1 and S2 was observed, at SL and HA, for both the ΔV˙E/ΔHR and V˙E/V˙CO2 methods for VCP estimation. A good agreement between the two methods (ΔV˙E/ΔHR vs. V˙E/V˙CO2) was found for both environmental conditions; the mean difference ± 2 SD of V˙O2 at VCP (VCP-V˙O2) was -22 ± 112 ml/min at SL and 39 ± 81 ml/min at HA. The VCP-V˙O2 was significantly lower at HA compared to SL; in addition, S1 and S2 mean values were significantly higher at HA compared to SL. CONCLUSION: At HA, VCP may be reliably estimated by the ΔV˙E/ΔHR method.